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Ethics of using animals in research and testing

Learn about animal welfare in scientific research and consider whether the benefits justify the harms to animals.

Last edited: 16/06/2026

Before you get started

Activity toolkit

More than 100 million animals are used in research and testing worldwide each year, including more than 2.5 million in the UK. Animals used in scientific procedures can and do experience pain, suffering, and distress, which can be severe. 

Animals may be used in research to help develop medicines, study diseases, improve veterinary care, or test the safety of chemicals, such as agricultural chemicals or food additives. Each research area raises specific animal welfare, ethical and scientific issues.

Identifying and considering ethical issues helps make thoughtful decisions about the right thing to do, taking into account harms to animals, the research area, the study's potential benefits, and whether it is justifiable to use animals to try to solve specific human problems.

Supporting documents
Duke of Edinburgh Worksheet (4 hours)

 

Videos
Can we phase out animal use in science?
Can we end ‘severe’ suffering of animals used in science?

 

Instructions

Carrying out your research

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Animal welfare in science

Watch the two videos in your activity toolkit. While watching, make notes on:

  • What kinds of suffering or welfare problems animals may experience
  • Why is it important that scientists try to reduce suffering?
  • What alternatives to using animals in research and testing are mentioned?
     

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The 3Rs

The principles of the 3Rs were developed to reduce the use and suffering and to improve the lives of animals used in science, in response to ethical and animal welfare concerns about animal research and testing. The 3Rs are Replacement, Reduction, and Refinement. Read more about the 3Rs here, and then look at the examples on the worksheet.


For each example:

  • Decide whether it is an example of Replacement, Reduction, or Refinement
  • Explain why
  • Describe how it could help to improve animal welfare, and reduce suffering and/or reduce ethical concerns

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Ask other people

As part of your research, reflect on the examples below. Then, discuss the examples below with 3–5 people and make notes on their responses using the questions on the worksheet.


Example 1 - Giving a rat a brain injury to try to understand the impact on brain functioning (for example, how memory is affected) and to assess potential treatments for humans who have experienced similar injuries.


Example 2 - Testing different flavours and strengths of e-cigarette liquids on mice to assess any potential negative effects on human health.


Example 3 - Trying to create and breed pigs with a specific genetic alteration that means they are less susceptible to a serious lung disease seen in many farmed pigs.

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Your conclusion

Using your research, reflections, and interviews, write a short conclusion answering: How can humans make responsible and compassionate decisions about using animals in research and testing?

celebrate your achievement

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